Qualitative Article matrix

Citation include any two: Problem addressed, purpose of research, or research question Literature Review Level of Evidence Study Design Population/ Sampling; Ethics Analysis Methods Findings and Conclusions Discussion and Limitations Implications for practice 1. Rider, V., Abdou, N. I., Kimler, B. F., Lu, N., Brown, S., & Fridley, B. L. (2018). Gender bias in human systemic lupus erythematosus: A problem of steroid receptor action? Frontiers in Immunology, 9. https://doi.org/10.3389/fimmu.2018.00611 The research evaluates the fundamental processes responsible for the substantial gender inequality observed in Systemic Lupus Erythematosus (SLE) because women develop SLE nine times more frequently than men. The study specifically evaluates estradiol together with estrogen receptor α (ERα) signaling networks in SLE T cells to determine their contribution toward disease onset. Previous investigations demonstrate that estradiol and other sex hormones participate in SLE development by affecting immune system functions. The research expands previous findings through an investigation of estrogen receptor-blocking effects on cells affecting SLE while utilizing Faslodex/ICI182,780. Additionally, the investigation examines the signaling relationship between ERα and glucocorticoid receptor (GR) while assessing posttranslational modifications involving ubiquitination and sumoylation because these modifications could lead to accelerated ERα turnover in SLE T cells. The second level of clinical evidence derives from experimental methods using both clinical trial results and laboratory studies pe...