Sex Linked Disorders

Sex-Linked Disorders
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Sex-Linked Disorders
Fragile X syndrome is a disorder that is linked to the X chromosome. The genetic condition leads to numerous developmental problems, which is the case for Mason, the 4-year-old boy. It is one of the most common forms of mental disorder inherited and leads to mental retardation. The phenotype includes macroorchidism, prominent ears, and also behavioral issues for the child (Berry-Kravis et al., 2018). The condition has a unique inheritance pattern that entails nonpenetrant males. The condition is more common in males than females, occurring in approximately one in 4,000 males and one in 8,000 females, and it arises due to mutations in the FMR1 gene (Hagerman et al., 2018). Just like in the case of Mason, individuals who have the condition tend to have delayed language and development by the age of 2 years.
The genetic aberration of the genetic disorder arises due to changes in the FMR1 gene, which is responsible for brain development. The FMR1 gene is responsible for making the FMRP protein whic...