Hepatic steatosis. Etiology and Risk Factors of Hepatic Steatosis
Purpose
This project is an in depth investigation of a health condition. It will allow for the expansion of knowledge and the
ability to generalize larger concepts to a variety of health conditions.
Course outcomes: This assignment enables the student to meet the following course outcomes:
1. Explain the pathophysiologic processes of select health conditions. (PO 1)
2. Predict clinical manifestations and complications of select disease processes. (PO 1, 8)
3. Correlate lifestyle, environmental, and other influences with changes in levels of wellness. (PO 1, 7)
Due date: Your faculty member will inform you when this assignment is due. The Late Assignment Policy applies
to this assignment.
Total points possible: 100 points
Preparing the assignment
Follow these guidelines when completing this assignment. Speak with your faculty member if you have questions.
1) Select a disease process that interests you.
2) Obtain approval of the selected disease process from the course faculty.
a. Faculty will share how to submit your topic choice for approval.
3) Write a 2‐3 page paper (excluding title and reference pages).
4) Include the following sections about the selected disease process (detailed criteria listed below and in the Grading
Rubric).
a. Introduction of disease ‐ 20 points/20%
• One paragraph (approximately 200 words)
• Includes disease description
• Includes epidemiology of disease
b. Etiology and risk factors ‐ 20 points/20%
• Common causes of the disease or condition
• Risk factors for the disease or condition
• Impact of age
• Prevalence based on gender,
• Influence of environment
• Genetic basis of disease
• Lifestyle influences
• All information supported by current literature
c. Pathophysiological processes ‐ 20 points/20%
• Describes changes occurring at the cellular, tissue, and/or organ level that contribute to the disease
process.
• Describes adaptation of the cells and body in response to the disease.
• Relates disease processes to manifested signs and symptoms.
d. Clinical manifestations and complications ‐ 20 points/20%
• Describes the physical signs and symptoms that are important in considering the presence of the disease.
• Identifies signs that contribute to diagnosis of the condition
• Identifies symptoms that contribute to diagnosis of the condition.
• Identifies complications of the disease.
• Discusses the implications to the patient when complications are left untreated.
e. Diagnostics ‐ 10 points/10%
• Includes list of common laboratory and diagnostic tests used to determine the presence of the disease.
2
NR283 Pathophysiology
RUA: Pathophysiological Processes Guidelines
NR283 Pathophysiological Processes Guidelines V4.docx Revised: 05/2018
21
• Discusses the significance of test findings in relation to the disease process.
f. APA Style and Organization ‐ 10 points/10%
• References are submitted with assignment.
• Uses appropriate APA format (6th ed.) and is free of errors.
• Grammar and mechanics are free of errors.
• Paper is 2‐3 pages, excluding title and reference pages
• At least two (2) scholarly, primary sources from the last 5 years, excluding the textbook, are provided
I included the rubric please follow this order thank you!
Hepatic Steatosis
Author Name
University Name
Fatty liver, also known as hepatic steatosis, is a medical condition in which large vacuoles of triglyceride fats accumulate in the liver through the process of steatosis. Despite so many causes, hepatic steatosis is said to be caused by the excessive use of alcohol and drugs, and obesity (Keramida et al., 2016). Sometimes the illness is associated with other complications given that all of them influence fat metabolism at cellular and organelle levels. When the natural process of fat metabolism gets disrupted, the fat droplets start accumulating in the liver, leading to hepatic steatosis. The disease is more common in obese and lazy people than those who are slim and remain active the whole day.
Etiology and Risk Factors of Hepatic Steatosis
The first few cases of hepatic steatosis were reported nearly 70 years ago. Until 1980, no treatment for the disease was found, and it was mostly left untreated. Eventually, a group of doctors described that surgical jejunoileal bypass is the best way to cure hepatic steatosis (Nagy, 2018). The main risk factors associated with hepatic steatosis are total parenteral nutrition, different surgical procedures, and medications. The disease is more common in adults than in children and teenagers and affects a large number of people in the United States, Europe, Asia, and Canada.
The Pathophysiological Process of the Disease
At the cellular level, fat droplets accumulate in the liver and surround the nucleus. Thus, the liver cells get filled with many fat particles that do not let those cells perform their function correctly (Nagy, 2018). If the disease remains untreated for several days or weeks, then the size of vacuoles increases tremendously. The nucleus is eventually pushed to the periphery of the cell, and it gives rise to macro-vesicular fatty changes. Defects in fatty acid metabolism are mainly responsible for the pathogenesis of hepatic steatosis, which may lead to a low level of energy in the body and result in excessive and unnecessary lipid storage in the liver.
Physical Signs and Symptoms
The physical signs of hepatic steatosis are fatigue, feelings of tiredness and restlessness, pain in the right abdomen, swelling, visible...
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