Discussion board questions #5

Discussion Board Questions#5 Name Institution Course and Code Professor Date Discussion Board Questions#5 Musculoskeletal System Question 2 Corticosteroids impair bone healing by disrupting the natural balance between bone formation and resorption. They reduce osteoblast activity, which leads to decreased bone formation by inhibiting key osteogenic genes and proteins like osteocalcin (Alfaedi et al., 2024). Simultaneously, corticosteroids increase osteoclast activity, resulting in enhanced bone resorption. This imbalance, with more bone being broken down than formed, causes a net loss in bone mass and mineral density. Additionally, corticosteroids impair calcium absorption in the intestines and increase calcium excretion through the kidneys, further contributing to bone demineralization (Alfaedi et al., 2024). These combined effects lead to conditions such as corticosteroid-induced osteoporosis, increasing the risk of fractures and impairing bone healing. Reference Alfaedi, S. A., Kubbara, M. F., Alaithan, A. A., Alhudhaif, H. M., Abdullah, A. a. A., Sahool, H. M., Jawad, M. S. A., Almatar, M. A., Alnakhli, I. R., & Altawili, M. A. (2024). Beneath the surface: explo...