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4 pages/≈1100 words
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Health, Medicine, Nursing
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English (U.S.)
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Topic:
Selecting source of literature
Essay Instructions:
Selecting sources of the literature
Locate a minimum of 15 peer-reviewed articles that describe the problem or issue and that support the proposed solution. Eight of the 15 articles must be research-based (e.g., a study which is qualitative, quantitative, descriptive, or longitudinal).
Preview each of the 15 articles chosen by reading the article abstracts and summaries.
Hint: Article abstracts and summaries provide a concise description of the topic, research outcomes, and significance of findings.
Hint: Refer to "RefWorks" and "Module 1: Checklist."
Perform a rapid appraisal of each article by answering the following questions (one to two sentences are sufficient to answer each question):
1.How does each article describe the nature of the problem, issue, or deficit you have identified?
2.Does each article provide statistical information to demonstrate the gravity of the issue, problem, or deficit?
3.What are example(s) of morbidity, mortality, and rate of incidence or rate of occurrence in the general population?
4.Does each article support your proposed change?
Prepare this assignment according to the APA guidelines found in the APA Style Guide, located in the Student Success Center. An abstract is not required.
Essay Sample Content Preview:
Selecting Sources of Literature
Student:
Professor:
Course title:
Date:
Selecting Sources of Literature
For this research, the identified problem is adults with total knee replacement (TKR) and the proposed solution is low-molecular-weight heparin, also known as nadroparin, in preventing deep-vein thrombosis (DVT) after TKR. The PICOT question is: in adults who have undergone TKR (P), Nadroparin (I) is more effective than other therapies such as mechanical prophylaxis (C) in preventing deep-vein thrombosis (O). In this paper, 15 peer-reviewed articles that describe the problem and that support the proposed solution are described.
Article 1: Giannoni, M. F., Ciatti, R., Capaccia, L., Ruggiero, M., Dauri, M., & Mariani, P. P (2009). Total Knee Replacement: Prevention of Deep-Vein Thrombosis Using Pharmacological (Low-Molecular-Weight Heparin) and Mechanical (Intermittent Foot Sole Pump System) Combined Prophylaxis. Preliminary Results.
This article is research-based. In their study, the Giannoni et al (2009) sought to determine the role of combined pharmacological and mechanical prophylaxis in preventing deep venous thrombosis following total knee replacement. The design was prospective case series study. Thirty-eight total knee procedures were performed on 34 patients, and four patients had bilateral TKR. Patients were given injection of nadroparin calcium and observed for 15 days. Their findings showed that nadroparin calcium greatly reduced the occurrence of DVT implying that it is effective in preventing DVT infections after TKR.
Article 2: Blanchard, Y., Meuwly, P., Leyvraz, M., Miron., Bounameaux, H., Hoffmeyer, P., Didier, D., & Schneider, P. (2010). Prevention of Deep-Vein Thrombosis after Total Knee Replacement. The Journal of Bone and Joint Surgery.
This article is research-based. Total Knee Arthroplasty (TKA) is linked to a major risk of getting DVT, as well as pulmonary embolism. The incidence of total deep-vein thrombosis after total knee arthroplasty is between 40 percent – 84 percent, with a prevalence of proximal deep-vein thrombosis that has a higher potential to bring about pulmonary embolism (Blanchard et al., 2010). One everyday subcutaneous injection of nadroparin in a weight-adjusted, fixed dosage scheme is better and much superior than intermittent pneumatic compression of the foot for thromboprophylaxis following total knee arthroplasty (Blanchard et al., 2010).
Article 3: Warwick, D. (2012). Prevention of Venous Thromboembolism in Total Knee and Hip Replacement. Circulation.
Operations for knee and hip replacement are today commonly done, about 1 million every year in Europe and roughly the same number in the United States. As an injectable agent, low-molecular-weight heparin is effective in reducing venous thromboembolism and preventing DVT (Warwick, 2012).
Article 4: Duplaga, B. A., Pharm, D., Christina, W., & Edith, N. (2009). Dosing and Monitoring of Low-Molecular-Weight Heparins in Special Populations. Pharmacotherapy; 21(2):218-234.
This article is research-based. The authors assert that many meta-analysis and clinical trials have emerged that support the relative safety and superior efficacy of low-molecular-weight heparins relative to unfractionated heparin as the preferred antithrombotic agents for preventing and treating pulmonary embolism and deep vein thrombosis.
Article 5: Shawabkeh, J. S., Ghnaimat, M. M., & Hijazi, A. M. (2009). Pharmacologic Prophylaxis and Treatment and Treatment of Venous Thromboembolism after Knee Arthroplasty.
This article is research-based. The authors sought to assess the effectiveness of low-molecular-weight heparins (LMWH), warfarin and unfractionated heparin utilized for preventing venous thromboembolism in total knee arthroplasty. There was a substantially low prevalence of PE and DVT in patients who used low-molecular-weight heparins as prophylaxis compared to those who used unfractionated heparin (Shawabkeh et al., 2009). LMWH is effective in preventing DVT and should be used widely.
Article 6: Nocolaides, A. N., Fareed, J., Kakkar, A., Breddin, H. K., Goldhaber, S. Z., Kakkar, V. V., Michiels, J. J., Myers, K., Samana, M., Sasahara, A., & Kalodiki, E. (2010). Prevention and Treatment of Venous Thromboembolism. International Consensus Statement. Int Angiol; 25:101-161.
This article is research-based. A randomized controlled research showed that low-molecular-weight heparin was more effective compared to placebo since it lowered venographically detected DVT from 65 percent within the placebo group to 19 percent in the low-molecular weight heparin group. As such, LMWH should be used after TKR to prevent DVT from occurring.
Article 7: Argun, M., Oner, M., Saglamoglu, M., Karaman, I., Guney, A., Halici, M., & Kafadar, I. H. (2013). Fondaparinux Versus Nadroparin for Prevention of Venous Thromboembolism after Elective Hip and Knee Arthroplasty.
This article is research-based. The researchers sought to assess the safety and effectiveness of nadroparin compared with fondaparinux in preventing venous thromboembolism following arthroplasty. Nadroparin is superior than fondaparinux in preventing DVT and should be utilized in preventing DVT after TKR (Argun et al., 2013).
Article 8: Thirugnanam, S., Pinto, R., Cook, D., Geerts, W. H., & Fowler, R. A. (2012). Economic Analyses of Venous Thromboembolism Prevention Strategies in Hospitalized Patients: A Systematic Review. Critical Care.
This article is research-based. Venous thromboembolism happens in nearly 40 percent of hospitalized surgical and medical patients in the absence of prophylactic anticoagulation. Suitable usage of prophylaxis in preventing venous thromboembolism in patients who are at risk is a major patient-safety intervention for healthcare organizations. LMWH are the most effective and economically attractive strategy than warfarin, unfractionated heparin or placebo (Thirugnanam et al., 2012).
Article 9: Wang, C. J., Wang, J. W., Weng, L. H., Hsu, C. C., Huang, C. C., & Yu, P. C. (2011). Prevention of Deep-Vein Thrombosis after Total Knee Arthroplasty in Asian Patients. Comparison of Low-Molecular-Weight Heparin and Indomethacin. Journal of Bone and Joint Surgery; 86(1):136-40.
This article is research-based. Relative to no prophylaxis, indomethacin and LMWH greatly reduced the prevalence of DVT following TKA. As such, LMWH against DVT is warranted and should be used in patients after TKR/TKA (Wang et al., 2011).
Article 10: Martin, G. M., Thornhill, T. S., Katz, J. N. (2013). Complications of T...
Student:
Professor:
Course title:
Date:
Selecting Sources of Literature
For this research, the identified problem is adults with total knee replacement (TKR) and the proposed solution is low-molecular-weight heparin, also known as nadroparin, in preventing deep-vein thrombosis (DVT) after TKR. The PICOT question is: in adults who have undergone TKR (P), Nadroparin (I) is more effective than other therapies such as mechanical prophylaxis (C) in preventing deep-vein thrombosis (O). In this paper, 15 peer-reviewed articles that describe the problem and that support the proposed solution are described.
Article 1: Giannoni, M. F., Ciatti, R., Capaccia, L., Ruggiero, M., Dauri, M., & Mariani, P. P (2009). Total Knee Replacement: Prevention of Deep-Vein Thrombosis Using Pharmacological (Low-Molecular-Weight Heparin) and Mechanical (Intermittent Foot Sole Pump System) Combined Prophylaxis. Preliminary Results.
This article is research-based. In their study, the Giannoni et al (2009) sought to determine the role of combined pharmacological and mechanical prophylaxis in preventing deep venous thrombosis following total knee replacement. The design was prospective case series study. Thirty-eight total knee procedures were performed on 34 patients, and four patients had bilateral TKR. Patients were given injection of nadroparin calcium and observed for 15 days. Their findings showed that nadroparin calcium greatly reduced the occurrence of DVT implying that it is effective in preventing DVT infections after TKR.
Article 2: Blanchard, Y., Meuwly, P., Leyvraz, M., Miron., Bounameaux, H., Hoffmeyer, P., Didier, D., & Schneider, P. (2010). Prevention of Deep-Vein Thrombosis after Total Knee Replacement. The Journal of Bone and Joint Surgery.
This article is research-based. Total Knee Arthroplasty (TKA) is linked to a major risk of getting DVT, as well as pulmonary embolism. The incidence of total deep-vein thrombosis after total knee arthroplasty is between 40 percent – 84 percent, with a prevalence of proximal deep-vein thrombosis that has a higher potential to bring about pulmonary embolism (Blanchard et al., 2010). One everyday subcutaneous injection of nadroparin in a weight-adjusted, fixed dosage scheme is better and much superior than intermittent pneumatic compression of the foot for thromboprophylaxis following total knee arthroplasty (Blanchard et al., 2010).
Article 3: Warwick, D. (2012). Prevention of Venous Thromboembolism in Total Knee and Hip Replacement. Circulation.
Operations for knee and hip replacement are today commonly done, about 1 million every year in Europe and roughly the same number in the United States. As an injectable agent, low-molecular-weight heparin is effective in reducing venous thromboembolism and preventing DVT (Warwick, 2012).
Article 4: Duplaga, B. A., Pharm, D., Christina, W., & Edith, N. (2009). Dosing and Monitoring of Low-Molecular-Weight Heparins in Special Populations. Pharmacotherapy; 21(2):218-234.
This article is research-based. The authors assert that many meta-analysis and clinical trials have emerged that support the relative safety and superior efficacy of low-molecular-weight heparins relative to unfractionated heparin as the preferred antithrombotic agents for preventing and treating pulmonary embolism and deep vein thrombosis.
Article 5: Shawabkeh, J. S., Ghnaimat, M. M., & Hijazi, A. M. (2009). Pharmacologic Prophylaxis and Treatment and Treatment of Venous Thromboembolism after Knee Arthroplasty.
This article is research-based. The authors sought to assess the effectiveness of low-molecular-weight heparins (LMWH), warfarin and unfractionated heparin utilized for preventing venous thromboembolism in total knee arthroplasty. There was a substantially low prevalence of PE and DVT in patients who used low-molecular-weight heparins as prophylaxis compared to those who used unfractionated heparin (Shawabkeh et al., 2009). LMWH is effective in preventing DVT and should be used widely.
Article 6: Nocolaides, A. N., Fareed, J., Kakkar, A., Breddin, H. K., Goldhaber, S. Z., Kakkar, V. V., Michiels, J. J., Myers, K., Samana, M., Sasahara, A., & Kalodiki, E. (2010). Prevention and Treatment of Venous Thromboembolism. International Consensus Statement. Int Angiol; 25:101-161.
This article is research-based. A randomized controlled research showed that low-molecular-weight heparin was more effective compared to placebo since it lowered venographically detected DVT from 65 percent within the placebo group to 19 percent in the low-molecular weight heparin group. As such, LMWH should be used after TKR to prevent DVT from occurring.
Article 7: Argun, M., Oner, M., Saglamoglu, M., Karaman, I., Guney, A., Halici, M., & Kafadar, I. H. (2013). Fondaparinux Versus Nadroparin for Prevention of Venous Thromboembolism after Elective Hip and Knee Arthroplasty.
This article is research-based. The researchers sought to assess the safety and effectiveness of nadroparin compared with fondaparinux in preventing venous thromboembolism following arthroplasty. Nadroparin is superior than fondaparinux in preventing DVT and should be utilized in preventing DVT after TKR (Argun et al., 2013).
Article 8: Thirugnanam, S., Pinto, R., Cook, D., Geerts, W. H., & Fowler, R. A. (2012). Economic Analyses of Venous Thromboembolism Prevention Strategies in Hospitalized Patients: A Systematic Review. Critical Care.
This article is research-based. Venous thromboembolism happens in nearly 40 percent of hospitalized surgical and medical patients in the absence of prophylactic anticoagulation. Suitable usage of prophylaxis in preventing venous thromboembolism in patients who are at risk is a major patient-safety intervention for healthcare organizations. LMWH are the most effective and economically attractive strategy than warfarin, unfractionated heparin or placebo (Thirugnanam et al., 2012).
Article 9: Wang, C. J., Wang, J. W., Weng, L. H., Hsu, C. C., Huang, C. C., & Yu, P. C. (2011). Prevention of Deep-Vein Thrombosis after Total Knee Arthroplasty in Asian Patients. Comparison of Low-Molecular-Weight Heparin and Indomethacin. Journal of Bone and Joint Surgery; 86(1):136-40.
This article is research-based. Relative to no prophylaxis, indomethacin and LMWH greatly reduced the prevalence of DVT following TKA. As such, LMWH against DVT is warranted and should be used in patients after TKR/TKA (Wang et al., 2011).
Article 10: Martin, G. M., Thornhill, T. S., Katz, J. N. (2013). Complications of T...
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