Folate Deficiency Anemia
Review Chapter 20 in the Huether and McCance text. Reflect on the pathophysiological mechanisms of iron deficiency anemia.
Select one of the following types of anemia:
pernicious anemia, folate deficiency anemia, sideroblastic anemia, chronic inflammation anemia, or post-hemorrhagic anemia. Identify the pathophysiological mechanisms of the anemia you selected.
Consider the similarities and differences between iron deficiency anemia and the type of anemia you selected.
Reflect on how patient factors such as genetics, gender, ethnicity, age, and behavior might impact these anemic disorders.
Prochnow, C. (n.d.). Restoring hope: A cancer patient shares her story. Retrieved September 11, 2012, from http://www(dot)uwhealth(dot)org/uw-carbone-cancer-center/restoring-hope-a-cancer-patient-shares-her-story/20371
Huether, S. E., & McCance, K. L. (2012). Understanding pathophysiology (Laureate custom ed.). St. Louis, MO: Mosby.
McPhee, S. J., & Hammer, G. D. (2012). Pathophysiology of disease: An introduction to clinical medicine (Laureate Education, Inc., custom ed.). New York, NY: McGraw-Hill Medical.
Folate Deficiency Anemia
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Folate deficiency anemia
Pathophysiology involves the study of mechanism, manifestations, and conditions associated with a disease CITATION McP12 \l 1033 (McPhee, 2012). Folate deficiency anemia is also known as megaloblastic anemia is an anemic condition caused by the deficiency of folic acid, a type of vitamin B needed by the body to enhance the formation and growth of red blood cells.The description that can explain the pathophysiological mechanism of the anemia is that folate is present in the blood plasma in the basic form of 5-methyl THFA. Folate transporters such as ATP enable the THFA to enter into the cell CITATION Hue12 \l 1033 (Huether, 2012). Since the body does not store large quantities of folate, it is required that an individual should supplement the amount by eating food that have a considerable amount of folic acid. The disease is characterized pathologically by abnormally large red blood cells. The manifestation pathology of folate deficiency involves cell division impairment, homocysteine accumulation, and impaired methylation metabolic reactions. The methylation reactions are involved in regulating gene expression. It is the reason folate deficiency anemia augments chances of neoplastic risks to an individual. Other...