Discussion 2: Therapeutic Actions of Clotrimazole
Ms. Jones brings 6-week-old Sam to the clinic because of a bright red rash in the diaper area that has gotten worse since she started putting over-the-counter antibiotic cream on it 3 days ago. Sam is diagnosed with diaper Candida or a yeast infection. Clotrimazole (Lotrimin) topical TID for 14 days to the diaper area has been prescribed.
1. Briefly describe the therapeutic actions of Clotrimazole (Lotrimin).
2. Develop a teaching plan for Ms. Jones including age-appropriate considerations for Sam.
Submission Instructions:
-the initial post should be formatted and cited in the current APA style with support from at least 2 academic sources.
-All replies must be constructive and use literature where possible.
-Class book: Arcangelo, P. V., Peterson, M. A., Wilbur, V., & Reinhold, A. J. (2017). Pharmacotherapeutics for Advanced Practice: A Practical Approach (4th Ed.). Philadelphia, PA: Wolters Kluwer/Lippincott Williams & Wilkins.
Yeast Infection: A Case Study
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1 Briefly describe the therapeutic actions of Clotrimazole (Lotrimin).
Clotrimazole belongs to the imidazole class, which is used to treat fungal infections. Its site of action is at the fungal cytoplasmic membrane, where it alters the permeability of the barrier, leading to its breakage. Then, it prevents the production of ergosterol while utilizing the technique of concentration-dependent via the inhibition of the demethylation of fourteen alpha lanosterol. This process results in the lack of an intact and usable fungal cell membrane. Moreover, ergosterol directly stimulates the development of fungal cells. All of these lead to the dose-dependent prevention of fungal development (Khatter & Khan, 2021; Chrousos et al., 2015).
Aside from its anti-mycotic activities, it can also inhibit sarcoplasmic reticulum calcium adenosine triphosphatase production, stopping the stimulation of calcium-dependent potassium channels and voltage-dependent calcium channels and exhaustion of intracellular calcium (Khatter & Khan, 2021).
2 Develop a teaching plan for Ms. Jones, including age-appropriate considerations for Sam.
The teaching plan for Ms. Jones shall include primary, secondary, and tertiary prevention strategies concerning yeast infection. Primary prevention includes strategies to prevent incurring the disease. Secondary prevention includes strategies to detect the disease early in its course, and tertiary prevention entails treating the patient’s presenting symptoms (CDC, n.d.).
Primary Prevention
First, Ms. Jones shall be educated on diaper dermatitis, epidemiology, etiology, risk factors, and hygiene practices. Here, it is essential to educate the caregiver within their level of understanding and prevent medical terms. It would also be best to compare what they can see in their day-to-day living to understand the situation better.
What Is Diaper Dermatitis?
This is a condition where the diaper causes an inflammatory reaction at the perianal and perineal areas of the baby during prolonged use. This is quite a common condition, especially in younger babies.
Etiology
Bonifaz et al. (2016) reported that Candida albicans is the most common cause of superficial mycoses in babies, particularly in the skin disease diaper dermatitis. This has been recounted in more than eighty percent of those infected. The yeasts are secondary infections, which means that there could be a primary infection that reduced the child’s immunity, leading to another infection. However, this could also be secondary to the high load of the pathologic agent.
Predisposing Factors
Ms. Jones must be educated on the predisposing factors, which increase Sam’s risk of incurring diaper dermatitis. The caregiver must also understand how these factors affect the skin of the baby. The following are the factors: 1) Moisture. When this is increased, there is a higher chance of scratching the skin...