Understanding of Antimicrobial Resistance
********THIS ASSIGNMENT AND THE ONES TO FOLLOW BUILD OFF THE PREVIOUS ASSIGNMENT YOU COMPLETED. I HAVE UPLOADED THE LITERATURE TABLE OF EVIDENCE WHICH IS THE ASSIGNMENT***********************************************
The purpose of this assignment is to gather research to support your evidence-based project proposal. The research must be sufficient, compelling, relevant, and from peer-reviewed professional journal articles. Complete the following:
Refer to your problem statement and proposed topic to search for evidence-based research that supports your proposed project.
Find a minimum of 12 peer-reviewed journal articles that support your proposed topic. The articles must have been published within the last 5 years. You may begin with the reference list you created in Topic 1.
Review the "Rapid Critical Appraisal Checklists," located in Appendix B of the textbook and create a checklist or table to help evaluate the evidence and validity of each study. The specific checklist you choose will be determined by the type of evidence within the resource.
Once you have determined the validity and reliability of the article, use the "Literature Review: Table of Evidence" worksheet to document your articles. This table outlines the attributes of each study and documents the evidence that supports your proposed project. Using a summary table allows you to be more concise in your narrative description. Only research studies used to support your intervention are summarized in this table. You will refer to this table when you write your literature review, and as you develop your proposed solution in support of your intervention.
The "Rapid Critical Appraisal Checklists" and "Literature Review: Table of Evidence" submitted for this assignment are required as part of the appendices in the final paper.
While APA style is not required for the body of this assignment, solid academic writing is expected, and documentation of sources should be presented using APA formatting guidelines, which can be found in the APA Style Guide, located in the Student Success Center.
This assignment uses a rubric. Please review the rubric prior to beginning the assignment to become familiar with the expectations for successful completion.
You are required to submit this assignment to LopesWrite. Refer to the LopesWrite Technical Support articles for assistance.
Student Name:
-635513080Antimicrobial resistance is the biggest healthcare sector challenge in the 21st century. There is a need to address the challenge through the adoption of various measures including Next-Generation sequencing approach. 00Antimicrobial resistance is the biggest healthcare sector challenge in the 21st century. There is a need to address the challenge through the adoption of various measures including Next-Generation sequencing approach. Problem Statement:
Criteria
Article 1
Article 2
Article 3
Article 4
Article 5
APA-Formatted Peer-Reviewed Article Citation With Permalink
Kwong, S.M., Firth, N., and Jensen, S.O. (2018). Mobile Genetic Elements Associated with Antimicrobial Resistance, American Society for Microbiology Journal, 31(4), 1-61.
https://journals.asm.org/doi/full/10.1128/CMR.00088-17
Forde, B.M., Kidd, T.J., Harris, P.N., & Schembri, M.A. (2019). Antimicrobial Resistance in ESKAPE Pathogens, Clinical Microbiology Reviews, 33(3), 1-49.
https://journals.asm.org/doi/pdf/10.1128/CMR.00181-19
Boolchandani, M., D’Souza, A.W. & Dantas, G. (2019). Sequencing-based methods and resources to study antimicrobial resistance, Nature Reviews Genetics volume 20, pages356–370.
/publication/331880312_Sequencing-based_methods_and_resources_to_study_antimicrobial_resistance
Roope, L.S., Smith, R.D., Pouwels, K.B., Buchanan, J. & Abel, L. (2019). The challenge of antimicrobial resistance: What economics can contribute, Science Journal, 364(41),1-8. https://science.sciencemag.org/content/364/6435/eaau4679
Tacconelli, E. (2018). Surveillance for control of antimicrobial resistance, The Lancet Infectious Disease Journal, 18(3), 99-106.
/publication/320875152_Surveillance_for_control_of_antimicrobial_resistance
Article Title and Year Published
Mobile Genetic Elements Associated with Antimicrobial Resistance, 2018
Antimicrobial Resistance in ESKAPE Pathogens, 2019
Sequencing-based methods and resources to study antimicrobial resistance, 2019
The challenge of antimicrobial resistance: What economics can contribute, 2019
Surveillance for control of antimicrobial resistance, 2018
Research Questions (Qualitative)/Hypothesis (Quantitative), and Purposes/Aim of Study
What are the genetic aspects associated with antimicrobial resistance?
Establish the genetic aspects related to antimicrobial resistance.
How does antimicrobial resistance in ESKAPE pathogens occur?
Establish how antimicrobial resistance in ESKAPE pathogens occurs.
What are the sequencing-based methods necessary in studying antimicrobial resistance?
Highlight the sequence-based methods required in the study of antimicrobial resistance.
How can economics enhance the understanding of the cost of antimicrobial resistance?
Establish the economic contributions to the understanding of antimicrobial resistance.
Is surveillance in the control of antimicrobial resistance effective?
Establish the effectiveness of surveillance for controlling antimicrobial resistance.
Design (Quantitative, Qualitative, or Other)
Qualitative
Qualitative
Qualitative
Qualitative
Qualitative
Setting/Sample
-
-
-
-
-
Methods: Intervention/Instruments
Survey
Theoretical
Theoretical
Survey
Survey
Analysis
Horizontal gene transfer exposes one to the acquisition of antibiotic resistance.
Antibiotic resistance associated with ESKAPE pathogens results in severe infections and deaths.
The advanced techniques of antimicrobial gene discovery, like functional metagenomics, effectively discover antimicrobial resistance genes.
The cost of antimicrobial resistance is high.
There is a need to ascertain the appropriateness of antibiotic formulary, antibiotic stewardship programs, public health interventions, infection control policies, and antimicrobial development.
Key Findings
Horizontal gene transfer plays a pivotal role in acquiring new properties like antibiotic resistance.
The ESKAPE pathogens require a globally coordinated approach to address the pathogen’s unique resistance to antibiotics.
The advanced technique of antimicrobial gene discovery’s efficacy s limited to the type of antimicrobial resistance genes they can detect.
The cost of antimicrobial resistance is unpredictable and uncertain.
The reduction of antimicrobial resistance requires high-quality and real-time surveillance data.
Recommendations
There is a need for improvement in the annotation methods.
There is a need for rapid diagnostic methods to identify bacterial pathogens quickly.
There is a need for the rapid and accurate identification of resistant genes to enhance testament plans for bacterial infections.
There is for improvement in the generation of new antibiotics.
There is a need to make antimicrobial resistance surveillance systems and the alignment between human and veterinary surveillance systems scientific.
Explanation of How the Article Supports Your Identified Barrier or Issue in Health Care
The article supports the antimicrobial resistance subject because it highlights the genetic elements associated with the phenomenon.
The article is relevant because it underscores the antimicrobial resistance phenomenon in ESKAPE pathogens.
The article involves the study of antimicrobial resistance; hence it is relevant to the topic.
The article entails the understanding of antimicrobial resistance from an economic perspective; hence it is relevant.
It concerns the surveillance for control of antimicrobial resistance.
Criteria
Article 1
Article 2
Article 3
Article 4
Article 5
APA-Formatted Peer-Reviewed Article Citation With Permalink
Saracino, I.M., Pavoni, M.,
Zullo, A., Fiorini, G., Lazzarotto, T.,
Borghi, C., Vaira, D.(2021). Next-Generation
Sequencing for the Prediction of the
Antibiotic Resistance in Helicobacter
pylori: A Literature Review,
Antibiotics, 10, 4, 1-37.
/2079-6382/10/4/437
Gunasekera S, Abraham S, Stegger M, Pang S, Wang P, Sahibzada S, et al. (2021). Evaluating coverage bias in next-generation sequencing of Escherichia coli. PLoS ONE 16(6): 253-268....
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